The 20 Best Slime Against Humanity Commanders in Magic Ranked

Slime Against Humanity | Illustration by Brent Hollowell

Relentless cards that let you play as many copies as you can stuff into a deck have a special place in Commander. These cards break the usual singleton restriction of the format, which leads creative brewers to seek how to surround them in a functional EDH deck.

Slime Against Humanity (SAH) brings an interesting wrinkle to the relentless card strategy. It fills your board with creatures, but it isn’t a creature itself, which means you need a different package than you would run for the likes of Persistent Petitioners or Relentless Rats.

So, which commanders should you run if you want to get the most out of your many copies of Slime Against Humanity? How do ooze commanders fare, and are there any interesting ways to leverage this Karlov Manor common?

One thing’s for sure: All this talk of slime has got me thinking: “Uh-Oh!”

What Are Slime Against Humanity Commanders in MTG?

The Mimeoplasm | Illustration by Svetlin Velinov

Slime Against Humanity (SAH) commanders are legendary creatures and other eligible commanders that synergize with the card of the same name from Murders at Karlov Manor.

Slime Against Humanity is a 3-mana green sorcery that creates a 0/0 Ooze token with trample, then places +1/+1 counters on it equal to 2 plus the number of cards named Slime Against Humanity you own in exile or in your graveyard. It’s also one of those relentless cards that allow you to play any number of copies of them in a deck.

Right away, you know that your Slime Against Humanity commander has to have green in its color identity. It could be an ooze commander, a +1/+1 counters commander, or a token commander. You can use self-mill abilities and discard to get copies of the card into your graveyard more quickly, you can exile them with delve, forage, or other abilities that exile cards from your graveyard, and you could even grant them abilities like flashback.

One disadvantage with Slime Against Humanity decks is that they cast a sorcery as their main source of creatures rather than cast creature spells. You can’t leverage cast triggers like Beast Whisperer or typal payoffs like Cavern of Souls the way that you would in another creature-based deck. But for some brewers, a “disadvantage” is more of a “deckbuilding puzzle”.

In other words: Challenge Accepted.

#20. Felix Five-Boots

Felix Five-Boots is a solid Sultai commander () that allows you to play most of the major oozes that aren’t Slime Against Humanity. You’ll need outside help to give your oozes saboteur triggers, because none of the ones in these colors have a trigger to double. You’ve got access to the likes of Bred for the Hunt and Bident of Thassa, though.

#19. Tasigur, the Golden Fang

Tasigur, the Golden Fang is a lot of fun here. Like Felix, you can play most of the oozes in Magic, plus you have +1/+1 counters and proliferation. You also somewhat mitigate the downside of how Tasigur’s activated ability makes an opponent choose which card to return to your hand; their options will be mostly Slime Against Humanity, and the only other things in the deck should be lands, interaction, and useful consistency and protection pieces. Talk about being caught between a rock and a slimy place.

#18. Quina, Qu Gourmet

Part of the appeal of Quina, Qu Gourmet, at least to me, is that it’s an uncommon. Since Slime Against Humanity is a common, you can build a Pauper Commander deck around this theme. Is it any good? Not a clue, but maybe I should try it out, because that seems like it could be fun.

#17. Gale, Waterdeep Prodigy + Master Chef

This feels like a niche within a niche, since Scion of Halaster is the more popular background for Gale, Waterdeep Prodigy. Master Chef makes for a Simic () combo, and the background adds extra +1/+1 counters. The deckbuilding issue is that to benefit from Gale’s trigger, you need to have instants to cast once your SAHs are in your graveyard. If your aren’t losing Ooze tokens constantly, that might not be so bad. Every copy in your library can count for two by the time you’ve cast it, then recast it with Gale. And that’s without any spell copying or token doubling to consider.

#16. Reyhan, Last of the Abzan + Slurrk, All-Ingesting

The partner pairing of Reyhan, Last of the Abzan and Slurrk, All-Ingesting is decent, but it’s not the best Golgari () option, not even the best ooze. Moving counters around is good and all, but for this strategy, death triggers are a failsafe, not a sign that things are going well.

#15. The Mimeoplasm

The problem with playing The Mimeoplasm as your Slime Against Humanity commander is that you rely entirely on your opponents to fuel its enters trigger. Since your creature base mainly comes from sorceries, SAH does nothing for your commander. The +1/+1 counters are a parallel synergy, at least.

#14. Katilda and Lier

The Slime Against Humanity build comes with a tricky balancing act for Katilda and Lier: You have to cast humans to give flashback to your SAHs, and even then it’s only one at a time.

#13. Falco Spara, Pactweaver

Bant () is a solid color combination if you want a slightly more controlling version of the Slime Against Humanity deck, and you have your pick of various counter payoffs here, too. Falco Spara, Pactweaver is one of them, since you can trade in your counters to cast the top card of your deck, no card type restrictions.

#12. Alaundo the Seer

Now here’s a Slime Against Humanity deck that could behave just like the slow creep of approaching ooze. Alaundo the Seer’s activated ability lets you exile cards with time counters on them to cast them later, something that effectively increases the size of your hand. But here’s the fun part: You can use time travel to accelerate the advance of any Slime Against Humanity you have in exile, and they all still count towards the +1/+1 counters of any SAH you cast in the meantime. You can establish a light board presence, then set yourself up to cast a bunch of Slime Against Humanity at the end of your opponent’s turn so that you don’t have to worry about haste enablers.

#11. Ziatora, the Incinerator

Ziatora, the Incinerator naturally takes a very Jund () take on the Slime Against Humanity archetype. As you might expect from a commander that flings something on your end step, the goal here is to make massive oozes that you can sacrifice to take out your opponents. Treasure tokens can be part of your ramp package, which can lead to a fairly high storm count before you cast a certain legendary ooze….

#10. Loot, the Key to Everything

The upkeep trigger that digs through your library gives Loot, the Key to Everything a good starting point to pair with Izzet’s (’s) spellslinging and Simic’s +1/+1 counters synergy. You can build your deck in a way to control the number of cards you exile each turn; presumably your deck is going to have creatures and artifacts, and maybe some enchantments like Doubling Season or Hardened Scales, but you can probably skip planeswalkers and battles.

#9. Codie, Vociferous Codex

Codie Slime has potential for a stompy combo build of sorts. The idea is to establish a board of Slime Against Humanity’s tokens before you activate Codie’s ability. Cast another SAH, which then filters the top of your library for an instant or sorcery with a mana value of 2 or less. There’s some potential: Maybe you use that to grab tutors that then grab your win conditions, like an Overrun or something. You can also just build a regular Magic deck, combos be darned, that uses SAH as the creature base and runs next to no nonland permanents and call it a day.

#8. Wort, the Raidmother

Thanks to conspire, Wort, the Raidmother makes it really easy to double up every time you cast a Slime Against Humanity. Gruul () +1/+1 counters has some other commanders and strategies that you can crib from, like Minsc & Boo, Timeless Heroes. SAH decks with red in them can also play Pyromancer Ascension, a card that doesn’t see much play in a singleton format.

#7. Shalai and Hallar

The Shalai and Hallar version of Slime Against Humanity puts a neat spin on burn. When you place +1/+1 counters, you deal damage to a target opponent. Counter doublers and damage doublers are your friends here, and you’ve got no shortage of Impact Tremors clones to increase the sources of damage.

#6. Illuna, Apex of Wishes

You might be wondering: “How to I balance a mutate commander with a Slime Against Humanity commander?” Answer: You cast your commander for its mutate cost. Illuna, Apex of Wishes lets you dig for your win conditions, like Karlach, Fury of Avernus. Raph & Mikey, Troublemakers is a viable option as another way to dig for what you need, when you need it.

#5. Adrix and Nev, Twincasters

A token doubler in the command zone is a good way to take advantage of a card like Slime Against Humanity, and Adrix and Nev, Twincasters is a really good 2-color option. Simic has lots of counter support to slip in the deck, too.

#4. Umori, the Collector

You won’t use it as a companion in this situation, but as a commander, Umori, the Collector is a very viable Slime Against Humanity option. When on the field, it acts as your first Emerald Medallion, which helps you to cast more SAHs each turn. There’s also the additional upside of black’s many tutors, so you can set up combo wins more consistently with Umori.

#3. Witherbloom, the Balancer

You just need two creatures on the board to turn Slime Against Humanity into a 1-mana spell with Witherbloom, the Balancer, which is perfect to crank up the storm count and lead into Aeve, Progenitor Ooze. Witherbloom itself is rather expensive, but that shouldn't hold it back too much. If you're willing to leave aside some good black removal and death payoffs, you can focus on green ramp and card draw in your build, with Beledros as the only card that needs black mana.

#2. Flubs, the Fool

Flubs, the Fool’s combination of abilities and color identity make for a strong choice to play Slime Against Humanity. Its spell cast and landfall triggers let you discard copies of SAH into your graveyard, and you have access to spellslinging cost reducers like Goblin Electromancer. It’s a great way to pump up your storm count before you drop another oozy threat….

#1. Aeve, Progenitor Ooze

You could almost make an “It’s the same picture” meme with Aeve, Progenitor Ooze and Slime Against Humanity. This ooze from Modern Horizons 2 is the perfect commander for a SAH strategy. It’s mono-green, so you don’t have to fill your deck (and budget) with color fixing, duals, tri-lands, etc. Aeve and SAH’s abilities synergize so well, too. Anything that benefits one benefits the other, like counter doublers and token doublers. It fits like a glove, no notes.

Example Decklist: Aeve, Progenitor Ooze in Commander

Aeve, Progenitor Ooze | Illustration by Andrew Mar

This mono-green commander deck uses 38 copies of Slime Against Humanity to illustrate what a higher SAH count looks like, though you can take out about 5-7 copies to make space for other utility and glue pieces.

You want to ramp as much as you can so that you can cast more and more SAHs. Ideally, you can get at least one cost reducer out (Emerald Medallion or The Earth Crystal) so that you can cast 1- or 2-mana SAHs and a 3- or 4-mana Aeve, Progenitor Ooze as soon as possible.

For games that get grindy, Craterhoof Behemoth and Worldly Tutor provide a possible win condition. But because so many slots are dedicated to Slime Against Humanity, I don’t have too much confidence in its win rate.

Adapting the Deck to Arena

Aeve, Progenitor Ooze is on MTG Arena thanks to Jumpstart: Historic Horizons, and Slime Against Humanity is much more accessible on the digital platform as a common from Murders at Karlov Manor.

Four cards that I included aren’t legal for Arena, though: Nature's Lore, Kodama's Reach, Oran-Rief, the Vastwood, and Thrumming Stone. You can replace the ramp spells with cards like Cycle of Renewal that fill similar roles. Oran-Rief, the Vastwood can sub out in favor of a basic Forest, or another MDFC like Khalni Ambush.

Thrumming Stone is a bit of a sticking point, though. There’s nothing available on Arena that remotely replaces it; even Mirror Box only pumps up nontoken creatures.

How Many Copies of Slime Against Humanity Should You Play?

The number of copies of Slime Against Humanity you run in your deck depends on the Bracket in which you want it to play and how much interaction, ramp, and other utility you want. You could, in theory, build a mono-green Aeve, Progenitor Ooze deck with 40 basic Forests, 59 copies of Slime Against Humanity, and that’s it. But if you do that, you have no ramp, no removal, no counter doublers, no token doublers… that build has a lot of space for improvement.

For me, the sweet spot is around 30-34 for decks that want to emulate a creature-heavy build or a typal deck. That gives you space for interaction and other utility to flesh out your deck.

Does Slime Against Humanity Count Itself?

No, it doesn’t. When you cast a copy of Slime Against Humanity, it doesn’t move from the stack to your graveyard until after it fully resolves. It doesn’t see itself in your graveyard (or exile, if a replacement effect is about to send it there), so it doesn’t count itself.

Commanding Conclusion

Felix Five-Boots | Illustration by Chris Rahn

Can you imagine what kind of shenanigans we’d get up to if Slime Against Humanity were a kindred card with the ooze creature type? That’s probably exactly why the design team only bring out kindred cards in very specific circumstances. But we can dream… and make customs and proxies….

Are there any commanders I haven’t listed that you’d use for Slime Against Humanity? How would you make a custom commander for this strategy? Let me know in the comments below or over on the Draftsim Discord.

Until next time, if your matches keep you from smiling, may you at least be sliming.